@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix sct: <http://snomed.info/id/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://hl7.org/fhir/MedicationRequest/medrx0317> a fhir:MedicationRequest;
  fhir:nodeRole fhir:treeRoot;
  fhir:Resource.id [ fhir:value "medrx0317"];
  fhir:DomainResource.text [
     fhir:Narrative.status [ fhir:value "generated" ];
     fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative</b></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource &quot;medrx0317&quot; </p></div><p><b>identifier</b>: id: 12345689 (OFFICIAL)</p><p><b>status</b>: completed</p><p><b>intent</b>: order</p><p><b>medication</b>: <a name=\"med0303\"> </a></p><blockquote><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource &quot;med0303&quot; </p></div><p><b>code</b>: Alemtuzumab 10mg/ml (Lemtrada) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/3.1.0/CodeSystem-v3-rxNorm.html\">RxNorm</a>#1594660)</span></p></blockquote><p><b>subject</b>: <a href=\"patient-pat1.html\">Patient/pat1: Donald Duck</a> &quot;Duck DONALD&quot;</p><p><b>authoredOn</b>: 2015-01-15</p><p><b>requester</b>: <a href=\"practitioner-f007.html\">Practitioner/f007: Patrick Pump</a> &quot;Simone HEPS&quot;</p><p><b>reasonCode</b>: Chronic Lymphoid Leukemia (disorder) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOMED CT</a>#92814006)</span></p></div>"
  ];
  fhir:DomainResource.contained [
     a fhir:Medication;
     fhir:index 0;
     fhir:Resource.id [ fhir:value "med0303" ];
     fhir:Medication.code [
       fhir:CodeableConcept.coding [
         fhir:index 0;
         fhir:Coding.system [ fhir:value "http://www.nlm.nih.gov/research/umls/rxnorm" ];
         fhir:Coding.code [ fhir:value "1594660" ];
         fhir:Coding.display [ fhir:value "Alemtuzumab 10mg/ml (Lemtrada)" ]
       ]
     ]
  ];
  fhir:MedicationRequest.identifier [
     fhir:index 0;
     fhir:Identifier.use [ fhir:value "official" ];
     fhir:Identifier.system [ fhir:value "http://www.bmc.nl/portal/prescriptions" ];
     fhir:Identifier.value [ fhir:value "12345689" ]
  ];
  fhir:MedicationRequest.status [ fhir:value "completed"];
  fhir:MedicationRequest.intent [ fhir:value "order"];
  fhir:MedicationRequest.medicationReference [
     fhir:Reference.reference [ fhir:value "#med0303" ]
  ];
  fhir:MedicationRequest.subject [
     fhir:link <http://hl7.org/fhir/Patient/pat1>;
     fhir:Reference.reference [ fhir:value "Patient/pat1" ];
     fhir:Reference.display [ fhir:value "Donald Duck" ]
  ];
  fhir:MedicationRequest.authoredOn [ fhir:value "2015-01-15"^^xsd:date];
  fhir:MedicationRequest.requester [
     fhir:link <http://hl7.org/fhir/Practitioner/f007>;
     fhir:Reference.reference [ fhir:value "Practitioner/f007" ];
     fhir:Reference.display [ fhir:value "Patrick Pump" ]
  ];
  fhir:MedicationRequest.reasonCode [
     fhir:index 0;
     fhir:CodeableConcept.coding [
       fhir:index 0;
       a sct:92814006;
       fhir:Coding.system [ fhir:value "http://snomed.info/sct" ];
       fhir:Coding.code [ fhir:value "92814006" ];
       fhir:Coding.display [ fhir:value "Chronic Lymphoid Leukemia (disorder)" ]
     ]
  ];
  fhir:MedicationRequest.dosageInstruction [
     fhir:index 0;
     fhir:Dosage.sequence [ fhir:value "1"^^xsd:integer ];
     fhir:Dosage.text [ fhir:value "Rapid daily-dose escalation, until tolerated, from 3 mg/d, and then 10 mg/d, to the recommended maintenance dose of 30 mg IV over 120 min, 3 times per wk on alternate days for up to 12 wk" ];
     fhir:Dosage.additionalInstruction [
       fhir:index 0;
       fhir:CodeableConcept.text [ fhir:value "Rapidly increase dose until tolerated" ]
     ], [
       fhir:index 1;
       fhir:CodeableConcept.text [ fhir:value "Administer on alternate days" ]
     ];
     fhir:Dosage.timing [
       fhir:Timing.repeat [
         fhir:Timing.repeat.duration [ fhir:value "12"^^xsd:decimal ];
         fhir:Timing.repeat.durationUnit [ fhir:value "wk" ];
         fhir:Timing.repeat.frequency [ fhir:value "3"^^xsd:positiveInteger ];
         fhir:Timing.repeat.period [ fhir:value "1"^^xsd:decimal ];
         fhir:Timing.repeat.periodUnit [ fhir:value "wk" ]
       ]
     ];
     fhir:Dosage.route [
       fhir:CodeableConcept.coding [
         fhir:index 0;
         a sct:47625008;
         fhir:Coding.system [ fhir:value "http://snomed.info/sct" ];
         fhir:Coding.code [ fhir:value "47625008" ];
         fhir:Coding.display [ fhir:value "Intravenous route (qualifier value)" ]
       ]
     ];
     fhir:Dosage.method [
       fhir:CodeableConcept.coding [
         fhir:index 0;
         a sct:422145002;
         fhir:Coding.system [ fhir:value "http://snomed.info/sct" ];
         fhir:Coding.code [ fhir:value "422145002" ];
         fhir:Coding.display [ fhir:value "Inject - dosing instruction imperative (qualifier value)" ]
       ]
     ];
     fhir:Dosage.doseAndRate [
       fhir:index 0;
       fhir:Dosage.doseAndRate.type [
         fhir:CodeableConcept.coding [
           fhir:index 0;
           fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/dose-rate-type" ];
           fhir:Coding.code [ fhir:value "ordered" ];
           fhir:Coding.display [ fhir:value "Ordered" ]
         ]
       ];
       fhir:Dosage.doseAndRate.doseQuantity [
         fhir:Quantity.value [ fhir:value "3"^^xsd:decimal ];
         fhir:Quantity.unit [ fhir:value "mg" ];
         fhir:Quantity.system [ fhir:value "http://unitsofmeasure.org" ];
         fhir:Quantity.code [ fhir:value "mg" ]
       ]
     ]
  ], [
     fhir:index 1;
     fhir:Dosage.sequence [ fhir:value "2"^^xsd:integer ];
     fhir:Dosage.text [ fhir:value "Rapid daily-dose escalation, until tolerated, from 3 mg/d, and then 10 mg/d, to the recommended maintenance dose of 30 mg IV over 120 min, 3 times per wk on alternate days for up to 12 wk" ];
     fhir:Dosage.additionalInstruction [
       fhir:index 0;
       fhir:CodeableConcept.text [ fhir:value "Rapidly increase dose until tolerated" ]
     ], [
       fhir:index 1;
       fhir:CodeableConcept.text [ fhir:value "Administer on alternate days" ]
     ];
     fhir:Dosage.timing [
       fhir:Timing.repeat [
         fhir:Timing.repeat.duration [ fhir:value "12"^^xsd:decimal ];
         fhir:Timing.repeat.durationUnit [ fhir:value "wk" ];
         fhir:Timing.repeat.frequency [ fhir:value "3"^^xsd:positiveInteger ];
         fhir:Timing.repeat.period [ fhir:value "1"^^xsd:decimal ];
         fhir:Timing.repeat.periodUnit [ fhir:value "wk" ]
       ]
     ];
     fhir:Dosage.route [
       fhir:CodeableConcept.coding [
         fhir:index 0;
         a sct:47625008;
         fhir:Coding.system [ fhir:value "http://snomed.info/sct" ];
         fhir:Coding.code [ fhir:value "47625008" ];
         fhir:Coding.display [ fhir:value "Intravenous route (qualifier value)" ]
       ]
     ];
     fhir:Dosage.method [
       fhir:CodeableConcept.coding [
         fhir:index 0;
         a sct:422145002;
         fhir:Coding.system [ fhir:value "http://snomed.info/sct" ];
         fhir:Coding.code [ fhir:value "422145002" ];
         fhir:Coding.display [ fhir:value "Inject - dosing instruction imperative (qualifier value)" ]
       ]
     ];
     fhir:Dosage.doseAndRate [
       fhir:index 0;
       fhir:Dosage.doseAndRate.type [
         fhir:CodeableConcept.coding [
           fhir:index 0;
           fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/dose-rate-type" ];
           fhir:Coding.code [ fhir:value "ordered" ];
           fhir:Coding.display [ fhir:value "Ordered" ]
         ]
       ];
       fhir:Dosage.doseAndRate.doseQuantity [
         fhir:Quantity.value [ fhir:value "10"^^xsd:decimal ];
         fhir:Quantity.unit [ fhir:value "mg" ];
         fhir:Quantity.system [ fhir:value "http://unitsofmeasure.org" ];
         fhir:Quantity.code [ fhir:value "mg" ]
       ]
     ]
  ], [
     fhir:index 2;
     fhir:Dosage.sequence [ fhir:value "3"^^xsd:integer ];
     fhir:Dosage.text [ fhir:value "Rapid daily-dose escalation, until tolerated, from 3 mg/d, and then 10 mg/d, to the recommended maintenance dose of 30 mg IV over 120 min, 3 times per wk on alternate days for up to 12 wk" ];
     fhir:Dosage.additionalInstruction [
       fhir:index 0;
       fhir:CodeableConcept.text [ fhir:value "Rapidly increase dose until tolerated" ]
     ], [
       fhir:index 1;
       fhir:CodeableConcept.text [ fhir:value "Administer on alternate days" ]
     ];
     fhir:Dosage.timing [
       fhir:Timing.repeat [
         fhir:Timing.repeat.duration [ fhir:value "12"^^xsd:decimal ];
         fhir:Timing.repeat.durationUnit [ fhir:value "wk" ];
         fhir:Timing.repeat.frequency [ fhir:value "3"^^xsd:positiveInteger ];
         fhir:Timing.repeat.period [ fhir:value "1"^^xsd:decimal ];
         fhir:Timing.repeat.periodUnit [ fhir:value "wk" ]
       ]
     ];
     fhir:Dosage.route [
       fhir:CodeableConcept.coding [
         fhir:index 0;
         a sct:47625008;
         fhir:Coding.system [ fhir:value "http://snomed.info/sct" ];
         fhir:Coding.code [ fhir:value "47625008" ];
         fhir:Coding.display [ fhir:value "Intravenous route (qualifier value)" ]
       ]
     ];
     fhir:Dosage.method [
       fhir:CodeableConcept.coding [
         fhir:index 0;
         a sct:422145002;
         fhir:Coding.system [ fhir:value "http://snomed.info/sct" ];
         fhir:Coding.code [ fhir:value "422145002" ];
         fhir:Coding.display [ fhir:value "Inject - dosing instruction imperative (qualifier value)" ]
       ]
     ];
     fhir:Dosage.doseAndRate [
       fhir:index 0;
       fhir:Dosage.doseAndRate.type [
         fhir:CodeableConcept.coding [
           fhir:index 0;
           fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/dose-rate-type" ];
           fhir:Coding.code [ fhir:value "ordered" ];
           fhir:Coding.display [ fhir:value "Ordered" ]
         ]
       ];
       fhir:Dosage.doseAndRate.doseQuantity [
         fhir:Quantity.value [ fhir:value "30"^^xsd:decimal ];
         fhir:Quantity.unit [ fhir:value "mg" ];
         fhir:Quantity.system [ fhir:value "http://unitsofmeasure.org" ];
         fhir:Quantity.code [ fhir:value "mg" ]
       ]
     ]
  ] .

<http://hl7.org/fhir/Patient/pat1> a fhir:Patient .

<http://hl7.org/fhir/Practitioner/f007> a fhir:Practitioner .

# - ontology header ------------------------------------------------------------

<http://hl7.org/fhir/MedicationRequest/medrx0317.ttl> a owl:Ontology;
  owl:imports fhir:fhir.ttl;
  owl:versionIRI <http://build.fhir.org/MedicationRequest/medrx0317.ttl> .

# -------------------------------------------------------------------------------------