@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix sct: <http://snomed.info/id/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://hl7.org/fhir/Evidence/example-stroke-alteplase-fatalICH> a fhir:Evidence;
  fhir:nodeRole fhir:treeRoot;
  fhir:Resource.id [ fhir:value "example-stroke-alteplase-fatalICH"];
  fhir:DomainResource.text [
     fhir:Narrative.status [ fhir:value "generated" ];
     fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n      <p>\n        &quot;Risk of fatal ICH with alteplase for stroke&quot; is a univariate risk estimate.\n      </p>\n	</div>"
  ];
  fhir:Evidence.url [ fhir:value "http://hl7.org/fhir/Evidence/example-stroke-alteplase-fatalICH"];
  fhir:Evidence.title [ fhir:value "Risk of fatal ICH with alteplase for stroke"];
  fhir:Evidence.status [ fhir:value "draft"];
  fhir:Evidence.useContext [
     fhir:index 0;
     fhir:UsageContext.code [
       fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/usage-context-type" ];
       fhir:Coding.code [ fhir:value "focus" ]
     ];
     fhir:UsageContext.valueCodeableConcept [
       fhir:CodeableConcept.text [ fhir:value "Stroke" ]
     ]
  ], [
     fhir:index 1;
     fhir:UsageContext.code [
       a sct:1386000;
       fhir:Coding.system [ fhir:value "http://snomed.info/sct" ];
       fhir:Coding.code [ fhir:value "1386000" ];
       fhir:Coding.display [ fhir:value "Intracranial hemorrhage" ]
     ];
     fhir:UsageContext.valueRange [
       fhir:Range.low [
         fhir:Quantity.value [ fhir:value "0"^^xsd:decimal ];
         fhir:Quantity.unit [ fhir:value "d" ]
       ];
       fhir:Range.high [
         fhir:Quantity.value [ fhir:value "7"^^xsd:decimal ];
         fhir:Quantity.unit [ fhir:value "d" ]
       ]
     ]
  ];
  fhir:Evidence.relatedArtifact [
     fhir:index 0;
     fhir:RelatedArtifact.type [ fhir:value "citation" ];
     fhir:RelatedArtifact.label [ fhir:value "Emberson 2014" ];
     fhir:RelatedArtifact.display [ fhir:value "Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials." ];
     fhir:RelatedArtifact.citation [ fhir:value "Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, et al;Stroke Thrombolysis Trialists' Collaborative Group. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet 2014 Nov 29;384(9958):1929-35 PMID 25106063" ];
     fhir:RelatedArtifact.url [ fhir:value "https://doi.org/10.1016/S0140-6736(14)60584-5" ]
  ];
  fhir:Evidence.description [ fhir:value "2.7% incidence of fatal intracranial hemorrhage within 7 days with alteplase in patients with acute ischemic stroke"];
  fhir:Evidence.variableDefinition [
     fhir:index 0;
     fhir:Evidence.variableDefinition.variableRole [
       fhir:CodeableConcept.coding [
         fhir:index 0;
         fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/variable-role" ];
         fhir:Coding.code [ fhir:value "population" ];
         fhir:Coding.display [ fhir:value "population" ]
       ]
     ];
     fhir:Evidence.variableDefinition.observed [
       fhir:link <http://hl7.org/fhir/Group/AcuteIschemicStroke>;
       fhir:Reference.reference [ fhir:value "Group/AcuteIschemicStroke" ];
       fhir:Reference.type [ fhir:value "Group" ];
       fhir:Reference.display [ fhir:value "adults with acute ischemic stroke" ]
     ];
     fhir:Evidence.variableDefinition.intended [
       fhir:link <http://hl7.org/fhir/Group/AcuteIschemicStroke>;
       fhir:Reference.reference [ fhir:value "Group/AcuteIschemicStroke" ];
       fhir:Reference.type [ fhir:value "Group" ];
       fhir:Reference.display [ fhir:value "adults with acute ischemic stroke" ]
     ]
  ], [
     fhir:index 1;
     fhir:Evidence.variableDefinition.variableRole [
       fhir:CodeableConcept.coding [
         fhir:index 0;
         fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/variable-role" ];
         fhir:Coding.code [ fhir:value "population" ];
         fhir:Coding.display [ fhir:value "population" ]
       ]
     ];
     fhir:Evidence.variableDefinition.observed [
       fhir:link <http://hl7.org/fhir/Group/Emberson-2014-IPD-MA-Alteplase-Cohort>;
       fhir:Reference.reference [ fhir:value "Group/Emberson-2014-IPD-MA-Alteplase-Cohort" ];
       fhir:Reference.type [ fhir:value "Group" ];
       fhir:Reference.display [ fhir:value "Emberson 2014 IPD-MA Alteplase Cohort" ]
     ];
     fhir:Evidence.variableDefinition.intended [
       fhir:link <http://hl7.org/fhir/Group/AcuteIschemicStrokeTreatedWithAlteplase>;
       fhir:Reference.reference [ fhir:value "Group/AcuteIschemicStrokeTreatedWithAlteplase" ];
       fhir:Reference.type [ fhir:value "Group" ];
       fhir:Reference.display [ fhir:value "adults with acute ischemic stroke treated with alteplase" ]
     ]
  ], [
     fhir:index 2;
     fhir:Evidence.variableDefinition.variableRole [
       fhir:CodeableConcept.coding [
         fhir:index 0;
         fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/variable-role" ];
         fhir:Coding.code [ fhir:value "measuredVariable" ];
         fhir:Coding.display [ fhir:value "measured variable" ]
       ]
     ];
     fhir:Evidence.variableDefinition.observed [
       fhir:link <http://hl7.org/fhir/EvidenceVariable/example-fatal-ICH-in-7-days>;
       fhir:Reference.reference [ fhir:value "EvidenceVariable/example-fatal-ICH-in-7-days" ];
       fhir:Reference.type [ fhir:value "EvidenceVariable" ];
       fhir:Reference.display [ fhir:value "fatal ICH" ]
     ];
     fhir:Evidence.variableDefinition.intended [
       fhir:link <http://hl7.org/fhir/EvidenceVariable/example-fatal-ICH-in-7-days>;
       fhir:Reference.reference [ fhir:value "EvidenceVariable/example-fatal-ICH-in-7-days" ];
       fhir:Reference.type [ fhir:value "EvidenceVariable" ];
       fhir:Reference.display [ fhir:value "fatal ICH" ]
     ]
  ];
  fhir:Evidence.synthesisType [
     fhir:CodeableConcept.coding [
       fhir:index 0;
       fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/synthesis-type" ];
       fhir:Coding.code [ fhir:value "IPD-MA" ];
       fhir:Coding.display [ fhir:value "individual patient data meta-analysis" ]
     ]
  ];
  fhir:Evidence.studyType [
     fhir:CodeableConcept.coding [
       fhir:index 0;
       fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/study-type" ];
       fhir:Coding.code [ fhir:value "RCT" ];
       fhir:Coding.display [ fhir:value "randomized trial" ]
     ]
  ];
  fhir:Evidence.statistic [
     fhir:index 0;
     fhir:Evidence.statistic.statisticType [
       fhir:CodeableConcept.coding [
         fhir:index 0;
         fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/statistic-type" ];
         fhir:Coding.code [ fhir:value "C44256" ];
         fhir:Coding.display [ fhir:value "Proportion" ]
       ]
     ];
     fhir:Evidence.statistic.quantity [
       fhir:Quantity.value [ fhir:value "0.026835741669"^^xsd:decimal ]
     ];
     fhir:Evidence.statistic.numberOfEvents [ fhir:value "91"^^xsd:nonNegativeInteger ];
     fhir:Evidence.statistic.sampleSize [
       fhir:Evidence.statistic.sampleSize.numberOfStudies [ fhir:value "9"^^xsd:nonNegativeInteger ];
       fhir:Evidence.statistic.sampleSize.numberOfParticipants [ fhir:value "3391"^^xsd:nonNegativeInteger ]
     ]
  ] .

<http://hl7.org/fhir/Group/AcuteIschemicStroke> a fhir:Group .

<http://hl7.org/fhir/Group/Emberson-2014-IPD-MA-Alteplase-Cohort> a fhir:Group .

<http://hl7.org/fhir/Group/AcuteIschemicStrokeTreatedWithAlteplase> a fhir:Group .

<http://hl7.org/fhir/EvidenceVariable/example-fatal-ICH-in-7-days> a fhir:EvidenceVariable .

# - ontology header ------------------------------------------------------------

<http://hl7.org/fhir/Evidence/example-stroke-alteplase-fatalICH.ttl> a owl:Ontology;
  owl:imports fhir:fhir.ttl;
  owl:versionIRI <http://build.fhir.org/Evidence/example-stroke-alteplase-fatalICH.ttl> .

# -------------------------------------------------------------------------------------