@prefix fhir: <http://hl7.org/fhir/> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix sct: <http://snomed.info/sct/> .

# - resource -------------------------------------------------------------------

[] a fhir:ActivityDefinition;
  fhir:Resource.id [ fhir:value "example-alteplase-dosing"];
  fhir:DomainResource.text [
     fhir:Narrative.status [ fhir:value "generated" ]
  ];
  fhir:ActivityDefinition.url [ fhir:value "http://example.org/fhir/ActivityDefinition/example-alteplase-dosing"];
  fhir:ActivityDefinition.name [ fhir:value "Alteplase Dosing for Stroke"];
  fhir:ActivityDefinition.status [ fhir:value "draft"];
  fhir:ActivityDefinition.experimental [ fhir:value "true"];
  fhir:ActivityDefinition.kind [ fhir:value "MedicationRequest"];
  fhir:ActivityDefinition.code [
     fhir:CodeableConcept.coding [
       fhir:index 0;
       fhir:Coding.system [ fhir:value "http://www.nlm.nih.gov/research/umls/rxnorm" ];
       fhir:Coding.code [ fhir:value "1155608" ];
       fhir:Coding.display [ fhir:value "alteplase injectable product" ]
     ]
  ];
  fhir:ActivityDefinition.intent [ fhir:value "order"];
  fhir:ActivityDefinition.dosage [
     fhir:index 0;
     fhir:Dosage.sequence [ fhir:value "1" ];
     fhir:Dosage.text [ fhir:value "give 10% of dose over 1 minute" ];
     fhir:Dosage.route [
       a sct:47625008;
       fhir:CodeableConcept.coding [
         fhir:index 0;
         a sct:47625008;
         fhir:Coding.system [ fhir:value "http://snomed.info/sct" ];
         fhir:Coding.code [ fhir:value "47625008" ];
         fhir:Coding.display [ fhir:value "Intravenous use" ]
       ]
     ];
     fhir:Dosage.doseAndRate [
       fhir:index 0;
       fhir:Dosage.type [
         fhir:CodeableConcept.coding [
           fhir:index 0;
           fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/dose-rate-type" ];
           fhir:Coding.code [ fhir:value "calculated" ];
           fhir:Coding.display [ fhir:value "Calculated" ]
         ]
       ];
       fhir:Dosage.dose [
         fhir:Quantity.value [ fhir:value "0.9" ];
         fhir:Quantity.system [ fhir:value "http://unitsofmeasure.org" ];
         fhir:Quantity.code [ fhir:value "mg/kg" ]
       ]
     ];
     fhir:Dosage.maxDosePerAdministration [
       fhir:Quantity.value [ fhir:value "90" ];
       fhir:Quantity.system [ fhir:value "http://unitsofmeasure.org" ];
       fhir:Quantity.code [ fhir:value "mg" ]
     ]
  ], [
     fhir:index 1;
     fhir:Dosage.sequence [ fhir:value "2" ];
     fhir:Dosage.text [ fhir:value "give remaining 90% of dose over 1 hour" ];
     fhir:Dosage.route [
       a sct:47625008;
       fhir:CodeableConcept.coding [
         fhir:index 0;
         a sct:47625008;
         fhir:Coding.system [ fhir:value "http://snomed.info/sct" ];
         fhir:Coding.code [ fhir:value "47625008" ];
         fhir:Coding.display [ fhir:value "Intravenous use" ]
       ]
     ];
     fhir:Dosage.doseAndRate [
       fhir:index 0;
       fhir:Dosage.type [
         fhir:CodeableConcept.coding [
           fhir:index 0;
           fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/dose-rate-type" ];
           fhir:Coding.code [ fhir:value "calculated" ];
           fhir:Coding.display [ fhir:value "Calculated" ]
         ]
       ];
       fhir:Dosage.dose [
         fhir:Quantity.value [ fhir:value "0.9" ];
         fhir:Quantity.system [ fhir:value "http://unitsofmeasure.org" ];
         fhir:Quantity.code [ fhir:value "mg/kg" ]
       ]
     ];
     fhir:Dosage.maxDosePerAdministration [
       fhir:Quantity.value [ fhir:value "90" ];
       fhir:Quantity.system [ fhir:value "http://unitsofmeasure.org" ];
       fhir:Quantity.code [ fhir:value "mg" ]
     ]
  ] .

# -------------------------------------------------------------------------------------